Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Hassan M.F.Madkour; Dr. Nizam Baloch

Authors

Hassan M.F.Madkour
Dr. Nizam Baloch

2-methyl-4h-chromen-4-one, carbon electrophiles and nucleophiles, leishmaniasis

Abstract

The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC 50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

Downloads

How to Cite

Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents. (2012). Global Journal of Science Frontier Research, 12(B7), 27-32. https://www.journalofscience.org/index.php/GJSFR/article/view/446

Download Citation

References

G Korkina, I Afanas'ev (1997) Unknown Title. 38, 151.

Angeles Martínez-Grau, José Marco (1997) Friedländer reaction on 2-amino-3-cyano-4H-pyrans: Synthesis of derivatives of 4H-pyran [2,3-b] quinoline, new tacrine analogues. 7(24), 3165-3170.

G Galati, P Brien, O" (2004) Unknown Title. 37, 287-303.

Jiraporn Ungwitayatorn, Weerasak Samee, Jutarat Pimthon (2004) 3D-QSAR studies on chromone derivatives as HIV-1 protease inhibitors. 689(1-2), 99-106.

T Nakatsuka, Y Tomimori, Y Fukuda, H Nukaya (2004) Unknown Title. 14, 3201-3203.

W Huang, Y Ding, Y Miao, M Liu, Y Li, G Yang (2009) Unknown Title. 44, 3687-3696.

K Lee, D Nam, C Moon, S Seo, J Lee, Y Lee (2006) Unknown Title. 41, 991-996.

J Mcclure, J Harborne, T Mabry, H Mabry (1975) The Flavonoids. 970-1055.

E Gamal, P Djemgou, M Tchuendem, B Ngadjui, P Tane, H Toshifumi (2007) Unknown Title. 62, 331-338.

Piero Valenti, Alessandra Bisi, Angela Rampa, Federica Belluti, Silvia Gobbi, Antonella Zampiron, Maria Carrara (2000) Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. 8(1), 239-246.

L. -C Lim, Y. -C Kuo, C.-J Chou (2000) Unknown Title. 63, 627-630.

Yan-Ping Shi, Abimael Rodríguez, Omayra Padilla (2001) Calyculaglycosides D and E, Novel Cembrane Glycosides from the Caribbean Gorgonian Octocoral Eunicea Species and Structural Revision of the Aglycon of Calyculaglycosides A−C. 64(11), 1439-1443.

J Bruneton, Pharmacognosy (1995) Phytochemistry and Medicinal Plants. 265.

Uwe Albrecht, Michael Lalk, Peter Langer (2005) Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents. 13(5), 1531-1536.

Y Deng, J Lee, M Ramamonjy, J Synder, S Des Etages, D Kanada, M Synder Unknown Title.

I Khan, M Avery, C Burandt, D Goins, J Mikell, T Nash, A Azadegan, L Walker (2000) Antigiardial Activity of Isoflavones from Dalbergia frutescens Bark. 63(10), 1414-1416.

Kenji Mori, Gérard Audran, Honoré Monti (1998) The First Synthesis of Coniochaetones A and (±)-B: Two Benzopyranone Derivatives. 1998(3), 259-260.

Jeffrey Harborne, Christine Williams (2000) Advances in flavonoid research since 1992. 55(6), 481-504.

P Djemgou, D Gatsing, M Kenmogne, D Ngamga, R Aliyu, A Adebayo, P Tane, B Ngadjui, E Seguin, G Adoga (2007) Unknown Title. 1(2), 65.

Santosh Diwakar, Sachin Bhagwat, Murlidhar Shingare, Charansing Gill (2008) Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: Synthesis, SAR, and in-vitro assessment. 18(16), 4678-4681.

G Beecher (2003) Unknown Title. 133, 3248-3254.

J Hoult, M Moroney, M Paya (1994) [44] Actions of flavonoids and coumarins on lipoxygenase and cyclooxygenase. 234, 443-454.

M Salem, A Hamed, A El‐shekeil, A Babaqui, H Madkour (1992) ChemInform Abstract: Some Reactions of 6‐Chloro‐2‐methyl‐4H‐1‐benzopyran‐4‐one. Part 2.. 24(19), 24-34.

M Salem, A Hamed, A El-Shekeil, A Babaqui, H Madkour (1990) Unknown Title. 12(3), 189-200.

A Hamed, H Madkour, I Al_Nuaimi, B Hussain (1994) Unknown Title. 90(5-6), 359-364.

Marwa Salem, Magda Marzouk, Salma Ali, Hassan Madkour (2012) Synthesis, structure characterization and biological evaluation of new 6,8-dichloro-2-methyl-4H-chromen-4-one derivatives. 3(2), 220-227.

Y Al-Kahraman, H Madkour, A Dildar, M Yasinzai (2010) Unknown Title. 15, 660-671.

Yasser Al-Kahraman, Hassan. Madkour, Dildar Ali, Masoom Yasinzai (2011) Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines. 15(2), 660-671.

Y Alkahraman, H Madkour, M Sajid, M Azim, I Bukhari, M Yasinzai (2011) Unknown Title. 6(1), 19-24.

Y Al-Kahraman, M Yasinzai, G Singh (2012) Unknown Title. 35(6), 1009-1013.

G Singh, Y Alkahraman, D Mpadi, M Yasinzai (2012) Unknown Title.

Hafen Mohamad El-Metwally El-Shaaer, Alexander Perjéssy, Pavol Zahradník, Margita Lácová, Zora Šusteková (1993) Infrared spectra and theoretical study of methyl, formyl and acetyl derivatives of chromones. 124(5), 539-548.

Winton Jones (1981) Aminolysis and hydrolysis of chromonyl oxazolones and some condensation reactions of 2-methylchromone leading to novel chromones. 1, 344.

R Gasparova, M Lacova (1995) Unknown Title. 60(7), 1178-1185.

K Rao (2002) Unknown Title. 41, 3333-3334.

S Ibrahim, H El-Shaaer, A Hassan (2002) A. Phosphorus Sulfur Silicon. 177, 151-159.