On the Role of Luminal Flow and Interstrut Distance in Modelling Drug Transport from Half-Embedded Drug-Eluting Stent

Prashanta Kumar Mandal; Akash Pradip Mandal

Authors

Prashanta Kumar Mandal
Akash Pradip Mandal

embedded drug-eluting stent; flow pulsatility; interstrut distance; convection; womersley number

Abstract

A model for investigating the transport of drug from a half-embedded drug-eluting stent (DES) is developed. Keeping the relevance of the physiological situation in view, the luminal drug transport is considered as an unsteady convection-diffusion process, while the drug transport within the arterial tissue is supposed to commence as a diffusion process. The Marker and Cell (MAC) method has been used to handle numerically the governing equations of motion for the luminal flow and the drug transport through the lumen and the tissue. The effects of quantities of significance such as Reynolds number (Re), Womersley number (α) and interstrut distance on the transport of drug through both the lumen and the tissue are quantitatively investigated. Our simulation predicts that the mean concentration of drug increases with the decreases of Reynolds number and with an increase in the Womersley number.

Downloads

How to Cite

On the Role of Luminal Flow and Interstrut Distance in Modelling Drug Transport from Half-Embedded Drug-Eluting Stent. (2017). Global Journal of Science Frontier Research, 16(F6), 37-52. https://www.journalofscience.org/index.php/GJSFR/article/view/1919

Download Citation

References

Subbu Venkatraman, Freddy Boey (2007) Release profiles in drug-eluting stents: Issues and uncertainties. 120(3), 149-160.

B Balakrishnan, A Tzafriri, P Seifert, A Groothuis, C Rogers, E Edelman (2005) Strut position, blood flow, and drug deposition implications for single and overlapping drug-eluting stents. 111, 2958-2965.

F Bozsak, J Chomaz, A Barakat (2014) Modeling the transport of drugs eluted from stents: physical phenomena driving drug distribution in the arterial wall. 13, 327-347.

Franz Bozsak, David Gonzalez-Rodriguez, Zachary Sternberger, Paul Belitz, Thomas Bewley, Jean-Marc Chomaz, Abdul Barakat (2015) Optimization of Drug Delivery by Drug-Eluting Stents. 10(6), e0130182.

Yu Chen, Yan Xiong, Wentao Jiang, Man Wong, Fei Yan, Qingyuan Wang, Yubo Fan (2016) Numerical simulation on the effects of drug-eluting stents with different bending angles on hemodynamics and drug distribution. 54(12), 1859-1870.

J Chesnutt, H Han (2015) Simulation of the microscopic process during initiation of stent thrombosis. 56, 182-191.

Rossella Fattori, Tommaso Piva (2003) Drug-eluting stents in vascular intervention. 361(9353), 247-249.

A Gogineni, T Ravigururajan (2014) Flow through coated and non-coated coronary stented arteries: an overview. 14(4), 344.

M Grassi, G Pontrelli, L Teresi, G Grassi, L Comel, A Ferluga, L Galasso (2009) Novel design of drug delivery in stented arteries: A numerical comparative study. 6(3), 493-508.

Z Hajiali, M Dabagh, N Debusschere, De Beule, M Jalali, P (2015) Tissue prolapse and stresses in stented coronary arteries: A computer model for multi-layer atherosclerotic plaque. 66, 39-46.

F Harlow, J Welch (1965) Numerical calculation of time -dependent viscous incompressible flow of fluid with free surface. 8, 2182-2193.

R Hill, Y Bakhai, A Dickson, R Walley, T (2004) Drug-eluting stents: an early systematic review to inform policy*1, *2. 25(11), 902-919.

Chao-Wei Hwang, David Wu, Elazer Edelman (2001) Physiological Transport Forces Govern Drug Distribution for Stent-Based Delivery. 104(5), 600-605.

T Inoue, K Croce, T Morooka, M Sakuma, K Node, D Simon (2011) Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis. 4, 1057-1066.

V Kolachalama, E Levine, E Edelman (2009) Luminal flow amplifies stentbased drug deposition in arterial bifurcations. 4, 8105.

V Kolachalama, A Tzafriri, D Arifin, E Edelman (2009) Luminal flow patterns dictate arterial drug deposition in stent-based delivery. 133, 24-30.

K Koskinas, Y Chatzizisis, A Antoniadis, G Giannoglou (2012) Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation. 59, 1337-1349.

G Lorenzini, E Casalena (2008) CFD analysis of pulsatile blood flow in an atherosclerotic human artery with eccentric plaques. 41, 1862-1870.

Akash Mandal, Prashanta Mandal (2016) Drug elution model of coronary stent: effects of stent embedment and binding of drug. 20(2), 150.

Akash Mandal, Sarifuddin, Prashanta Mandal (2015) An unsteady analysis of arterial drug transport from half-embedded drug-eluting stent. 266, 968-981.

S Mcginty, S Mckee, R Wadsworth, C Mccormick (2011) Modelling drug-eluting stents. 28, 1-29.

S Mcginty, S Mckee, C Mccormick, M Wheel (2015) Release mechanism and parameter estimation in drug-eluting stent systems: analytical solutions of drug release and tissue transport. 32(2), 163-186.

Peter Mchugh, Abdul Barakat, Sean Mcginty (2016) Medical Stents: State of the Art and Future Directions. 44(2), 274-275.

C Mckittrick, S Kennedy, K Oldroyd, S Mcginty, C Mccormick (2016) Modelling the Impact of Atherosclerosis on Drug Release and Distribution from Coronary Stents. 44(2), 477-487.

R Mongrain, R Leask, J Brunette, I Faik, N Bulman-Feleming, T Nguyen (2004) Numerical modeling of coronary drug eluting stents. 113, 443-458.

Caroline O'brien, Vijaya Kolachalama, Tracie Barber, Anne Simmons, Elazer Edelman (2013) Impact of flow pulsatility on arterial drug distribution in stent-based therapy. 168(2), 115-124.