GC-MS Analysis for Structural Identification and Bioactive Compounds in Methanolic Leaf Extract of Mallotus oppositifolius.
GCMS analysis, mallotus oppositifolius, anticonvulsant, neurotransmitter, sleep depressant
Abstract
The aim of the present study is to investigate the bioactive compounds from the leaf extract of Mallotus oppositifolius using GCMS analysis. The chromatogram showed nine peaks indicating the presence of nine compounds in the extract. The major phytocompounds in the leaf were Glutaconic anhydride with the highest concentration in the extract, 40.19 peak area %, RT 22.686 and molecular formula C 5 H 4 O 3 ; 2-Mercaptophenol with 18.23 peak area %, RT 22.068 and molecular formula C 6 H 6 OS. Iso-Valreic and Valeric acids with 12.39,2.53 peak area %, RT 3.676,7.037 and the same molecular formula C 5 H 10 O 2 which had been proposed to have anticonvulsant effect in valerian and act as neurotransmitter. Oleamide with the least concentration of 2.15 peak area %, RT 27.959 and molecular formula C 18 H 35 NO which could induce sleep in animals, being studied as a potential medical remedy for mood and sleep disorder and cannabinoid-regulated disorder. The phytochemicals in Mallotus oppositifolius could be of therapeutic importance.
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A Sofowora (1993) Medicinal Plants and Traditional Medicine in Africa. 2.
A Adekunle (2001) Ethnobotanical Studies of some Medicinal Plants from Lagos State of Nigeria. 14, 71-79.
H Burkill (1997) The Useful Plants of the West Tropical Africa. 2, 969.
B Oliver (1960) Medicinal Plants in Nigeria. 70.
A Adekunle, A Ikumapayi (2006) Antifungal property and phytochemical screening of the crude extracts of Funtumia elastica and Mallotus oppositifolius. 55(4), 219-223.
C Bremer Christensen, J Soelberg, C Stensvold, A Jäger (2015) Activity of Medicinal Plants from Ghana Against the Parasitic Gut Protist Blastocystis.
Harinantenaina Liva, Jessica Bowman, Peggy Brodie, Carla Slebodnick, Callmander Martin, W Rakotobe Etienne, Randrianaivo Richard, Rasamison Vincent, E, Gorka Alexander, Roepe Paul, D Cassera, Maria, Kingston David, G (2013) Antiproliferative and Antiplasmodial DimericPhloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1). 76(3), 388-393.
H Burkhill (1994) The Useful Plants of West Tropical Africa. 2, 144-150.
E Farombi, O Ogundipe, J Moody (2001) Antioxidant and Anti-inflammatory Activities of Mallotus oppositifolius in Model Systems. 30, 213-215.
K Kennedy, Priscilla Kukuia, Eric Mante, Elvis Woode, Donatus Ameyaw, Adongo (2014) Antidepressant Effects of Mallotus oppositifolius in Acute Murine Models. 324063.
K Bryce (1992) The Fifth kingdom. 451.
William Jensen (2007) The Origin of the Soxhlet Extractor. 84(12), 1913.
S Stein (1990) National Institute of Standards and Technology (NIST) Mass Spectral Database and Software.
Mc Lafferty, F (1986) Registry of mass spectral data.
Kyung-Hyun Cho, Joo-Heon Hong, Ki-Teak Lee (2015) Monoacylglycerol (MAG)-Oleic Acid Has Stronger Antioxidant, Anti-Atherosclerotic, and Protein Glycation Inhibitory Activities than MAG-Palmitic Acid. 13(1), 99-107.
Salvador Huitron Resendiz, Lhys Gombart, Benjamin Cravatt, Steven Henriksen (2001) Effect of Oleamide on Sleep and its Rlationship to Blood pressure, Body temperature and Locomotor activity in Rats. 172(1), 235-243.
V Studdert, C Gay, D Blood (2012) Saunders Comprehensive Veterinary Dictionary. 263.
R Mosenich, So (1996) The Clinical Approach to Classification of Seizures and Epileptic Syndromes. 71, 405-441.
L Squire, F Bloom, Mc Connell, S (2003) Fundamental Neuroscience. 391-416.
J Reddy, G Mannaerts (1994) Peroxisomal Lipid Metabolism. 14, 343.
K Robert, Murray, K Daryly, Victor Granner, Rodwell (1998) Unknown Title. 27, 189.
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