Ultravist Studies on the Histological Patterns of the Kidney of Adult Wistar Rats
kidney, wistar rats, ultravist, hyper cellular mesangium
Abstract
The aim of this study was to assess the effects of ultravist on the histological patterns of the kidney of the Wistar rat. Thirty (30) Wister rats weighing between 182-212kg/BW were divided into three groups of ten (10) animals each. Group A served as the control group, while group B and C served as experimental groups receiving low and high dosage of ultravist (iopromide) which is the Radiographic Contrast Medium (RCM) used for the experiment respectively. Collection of tissues was carried out on rats at intervals of 30 minutes, 60 minutes, 2 hours, 12 hours and 24 hours following administration of RCM on the experimental groups. The sampling from experimental and control groups were carried out simultaneously following administration of low and high dose of RCM to rats from experimental groups. The result obtained for ultravist after one hour administration presented in plates 2 and 4 showed alteration in the high dose animals while plates 3 and 5 showed marked alterations in the cellular morphology of the kidney of the low dose animals.
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N Berg, H Idbohrn, B Wendeberg (1958) Investigation of tolerance of the rabbit's kidney to newer contrast media in renal angiography. 50, 285.
E Burns, G Dobben, T Kruckeberg (1981) Blood -brain barrier: morphology, physical and effects of contrast media. 3(1), 159-165.
Rs Cotran, Kumar, ; Vinay, Nelson Fausto, Stanley Robbins, Abbas, K Abul (2005) Robbins and Cotran pathologic basis of disease.
M Hoffmann, A Tielbeck, W Krause (2000) Haemostatic effects of low osmolar nonionic and ionic contrast media: a double blind comparative study. 73, 248-255.
H Katayama, K Yamaguchi, T Kozuka, T Takashima, P Seez, K Matsuura (1990) Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media.. 175(3), 621-628.
Marshall Gill (2006) iodinated contrast agentsthe state of the art: Synergy imaging and Therapy practice. 18-23.
Marshall Gill (2006) iodinated contrast agentsinduced nephrotoxcity. 18-21.
Marc Meth, Howard Maibach (2006) Current Understanding of Contrast Media Reactions and Implications for Clinical Management. 29(2), 133-141.
S Morcos (2003) Effects of radiographic contrast media on the lung. 76, 290-295.
Stanley Rapoport, Herbert Levitan (1974) NEUROTOXICITY OF X-RAY CONTRAST MEDIA. 122(1), 186-193.
F Shellock, E Kanal (1999) Safty of magnetic resonance imaging contrast agents. 10(3), 477-484.
U Speck (1993) Contrast media; overview, use and pharmaceutical aspects. 1-119.
H Thomsen, S Morcos (2000) Radiographic contrast media. 86(s1), 1-10.
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2015-05-09
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