rpl-11.1 Knockdown Disturbs Translation Machinery and Proteostasis in Caenorhabditis Elegans

Zishuo Sam Li; Jocelyne Mills; Dennis Bonal; Callie Millette

doi:10.34257/GJSFRCVOL24IS1PG1

Authors

Zishuo Sam Li
Jocelyne Mills
Dennis Bonal
Callie Millette

rpl-111; caenorhabditis elegans; RNAi; ubiquitin-proteosome system; selective autophagy; germline apoptosis

Abstract

An array of human chronic diseases, such as Alzheimer's disease, Huntington's disease, and Parkinson's disease, are related to defects in cellular proteostasis and the formation of protein aggregates. Using Caenorhabditis elegans PP563, a model organism developed for studying proteostasis stress, we can elucidate the biological role of specific genes and proteins involved in translation and proteostasis, advancing our understanding of relevant pathologies and therapeutics. Here, we report the knockdown of rpl-11.1 in C. elegans leads to disturbance in protein translation and proteostasis pathways, including the Ubiquitin-Proteosome System (UPS) and selective autophagy. We confirmed the importance of rpl-11.1 in ensuring correct ribosome biogenesis and translation accuracy.

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rpl-11.1 Knockdown Disturbs Translation Machinery and Proteostasis in Caenorhabditis Elegans. (2024). Global Journal of Science Frontier Research, 24(C1), 1-7. https://doi.org/10.34257/GJSFRCVOL24IS1PG1

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Zishuo Sam Li, Jocelyne Mills, Dennis Bonal, Callie Millette (2024) rpl-11.1 Knock-Down Disturbs Translation Machinery and Proteostasis in Caenorhabditis elegans. 1-7.